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| Thesis Name： |
Determination of norfloxacin using an electrochemically pretreated glassy carbon electrode |
| Usage： |
electrochemistry |
| Keyword： |
Norfloxacin; Glassy carbon electrode; Electrochemical pretreatment; Capsule analysis |
| Remarks： |
Abstract The electrochemical behaviors of norfloxacin on a pretreated glassy carbon electrode were investigated by cyclic voltammetry. The results indicated that the process was irreversible and fundamentally controlled by adsorption. The solution conditions and instrumental parameters were investigated and optimized. An optimal curve of norfloxacin was got in 0.1 mol/L phosphate buffer solution of pH 5.29 at 100 mV/s after 2.0 min stirring at 0.3 V. Norfloxacin gave a sensitive adsorptive oxidative peak at 1.17 V (versus Ag-AgCl). The peak current was in linear relation to the norfloxacin concentration in the range of 0.5-5.0 mg/mL. The detection limit was 0.2 mg/mL. This method was used for determination of norfloxacin in capsule，and the RSD was below 2.0 %. Chromatography analysis was also carried out to confirm this method. Statistical analysis of the results using Student t-test and the variance ratio F-test showed no significant difference (p=0.95) between the performance of the two methods as regards to accuracy and precision.
Sun Hanwen, Xing Tao, Lian Kaoqi, Liang Shuxuan
(College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, China)
Received Apr. 22, 2006; Supported by the Specialized Research Funds of China Education Ministry (No.20050075003) |
| Original file： |
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