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Thesis Name: Rapid screening of cinchona alkaloid derived phase-transfer catalysts. Application in the optimization of a glycine imine alkylation.
Usage: glycine imine alkylation
Keyword: Rapid screening of cinchona alkaloid derived phase-transfer catalysts. Application in the optimizati
Remarks: A method for the rapid screening of cinchona alkaloid
derived asymmetric phase transfer catalysts is discussed.
In this approach the catalysts are generated in situ via Nand
O- alkylation of the parent alkaloid, prior to
performing the reaction of interest. The whole sequence
can be performed using a parallel synthesizer with online
HPLC, thus enabling large numbers of catalysts to be
generated and assessed in an efficient manner.
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