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Research Domain: materials chemistry, chemical biology and catalysis.
Keyword: The Institute of Chemistry, Academia Sinica
Research Production: Materials Chemistry and Nanoscience
There are four research projects in this category: (1) Organic field effect transistors, devices and materials, including the molecular design, crystal engineering, thin film morphology and molecular orientation controls on substrates, with a goal to increase the charge mobility and field effect mobility in organic thin films. (2) Light-harvesting and solar energy conversion, which develop organic, inorganic and hybrid materials that are capable of electron and energy transfer, with a goal of developing solar energy conversion devices. (3) Construction of functional organic molecules, in which molecular spacers that tether electron or energy donor and acceptors are designed and synthesized, with goals of developing molecular electronic devices and understanding the fundamental energy and electron transfer mechanisms. (4) Self-assembly nanometer-scaled structures: to design molecular shapes or functional groups, and to fabricate nano-meter scaled structured materials with specific sizes or shapes. By controlling over the density or reactivity of functional groups at the surface, we plan to offer a platform for future biomedical or optoelectronic applications.

Catalysis
The development and application of catalysts are highly correlated with the chemical industry and the study of catalysis has been an important direction of the Institute. Emphasis in the future includes (1) The development of fuel cells. Inspired by biological systems, we plan to design a system that reduces carbon dioxide to produce methane using light, and then use enzyme derived model systems to convert methane to methanol, which is then oxidized to produce electric energy. (2) The development and application of nano-meter scaled catalysts, where properties are often distinctly different from that of other scales, this may bring a new application. Teams in the Institute have been developing silicon oxide composite materials, and studying their catalytic efficiencies in nitration and polymerization reactions. Metal and titian oxide catalysts on porous materials are also under an intense study. Answering the call for green chemistry, we have also been developing novel ionic liquids for future reaction solvent.

Chemical Biology
In recent years, the Institute of Chemistry has been developing researches in the area of chemical biology with very good progresses. In the future, we will focus on: (1) Structure of biological molecules. We will continue on the study of protein folding dynamics and mechanism. With spectroscopic information we plan to study the orientation and structure in the Particulate Methane Monooxygenase in its membrane, in order to understand the tertiary structure inside the membrane. Cryo electron microscopy will also be used to obtain protein structures in atomic resolutions. We have also studied the formation of triple stranded DNA, which is potentially able to alter gene expression or functions, for the future application in medicine or biotechnologies. (2) Developing new glycolipid derivatives for anti-cancer and antibiotics drug developments, which is a multidisciplinary project that requires expertise from areas of synthetic chemistry, structural biology, bioanalytical chemistry, proteomics and immunology. (3) Studying the virus infection mechanisms; developing antiviral and anticancer vaccines, new inhibitors and antibodies for HIV and SARS coronavirus; developing carbohydrate-encapsulated nanoparticles as a rapid target protein identification technique. 
Remarks: The Institute of Chemistry was among the first several institutes established when Academia Sinica was founded in 1928 inNanking, China. During its first two decades, despite the difficult times of World War II, the Institute managed to grow and contribute to chemistry research in China. In 1949, Academia Sinica was moved to Taiwan, and eventually relocated to the present site at Nankang, Taipei. In 1957, the Institute of Chemistry was reinstated in Taiwan.

Until1970's,earlier research was focused on applied chemistry related to, for example, fermentation, food chemistry and starch chemistry. During this period, the support from the government was limited. It was not until 1980 when the economic situation in Taiwan had been significantly improved that steady progress in research at Academia Sinica was achieved. The Institute of Chemistry has benefited from the economic growth of the island. Many of our colleagues were recruited during this period. In 1983 the Institute was moved in the modern five-story Chien Shih-Liang Memorial Hall, and in 1995 a second eight-story research laboratory was built. Research interests of our colleagues were expanded to organic synthesis, organometallic chemistry, structural chemistry and the chemistry of materials. However, lack of manpower was the major obstacle for research at this Institute. Even under these circumstances, research continued its steady growth.

Since the mid-nineties, the research programs of the Institute have been regrouped into three main areas: materials chemistry, chemical biology and catalysis. Colleagues with backgrounds in synthesis, analytical chemistry and computational chemistry work together on integrative research programs in the above areas.

URL:http://www.sinica.edu.tw/chem/ 
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