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| Research Domain： |
cell cycle regulation, cell cycle checkpoint, DNA damage, DNA repair, genomic stability, chemical biology, ATR kinase, signal transduction |
| Keyword： |
Karlene A. Cimprich, Ph.D. |
| Research Production： |
Research Description:
My lab is focused on understanding the mechanism that the cell uses to maintain genomic stability, with an emphasis on DNA damage checkpoints. Components of these checkpoints effectively monitor the status of the genome, sensing the presence of DNA damage and coordinating a range of possible responses, including DNA repair, apoptosis, arrest of cell cycle progression, and maintenance of replication fork stability. Loss of this checkpoint response is a hallmark of cancer cells and is one of the early steps in the development of cancer.
We are studying the DNA damage response using both cell-free extracts derived from the eggs of the frog Xenopus laevis as well as cultured mammalian cells. We are using these systems and a range of multidisciplinary techniques to understand how the checkpoint is activated following DNA damage and how this pathway is integrated with the processes of DNA replication, cell cycle progression and DNA repair.
Specific areas of current interest are:
• Checkpoint Activation.
• Checkpoint Signaling .
• Chemical Modulation of Checkpoint Pathways . |
| Remarks： |
Karlene A. Cimprich, Ph.D. (Assistant Professor)
Departmental Affiliation(s): Chemical and Systems Biology
Graduate Program(s): Cancer Biology, Chemical and Systems Biology
Other Affiliation(s): Chemistry
Phone: (650) 498-4720
Location: James H. Clark Center, Room W350B
Email: cimprich@stanford.edu
Website: http://cimprich.stanford.edu |
| Original file： |
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Promulgator Info |
| Full name: |
administrator |
| Country: |
CN |
| City: |
Dalian |
| Company Name: |
teloon Soft Strategy Co.,LTD |
| Homepage: |
http://www.hichem.com |
| E-mail: |
reply |
| Phone: |
86-411-82811662 |
| Fax: |
86-411-82819667 |
| Company Address: |
26 Renmin Road ,Dalian China |
| Zip/Postal Code: |
116001 |
| Introduction: |
As a professional E-information service platform with authoritative news and reports in chemical industry of chinese export and import market.Hichem has been received universally and praised highly since its established in 2001.In 2003,by joint effort of teloon chemicals and teloon soft strategy company(TSSC),Hichem team endeavored to recomposition the site ascribed to market requirement as well as offering our better service.Hichem focused on business to biusiness of new chemicals,fine chemicals,high chemicals and special chemicals.So naturally it is the very one-stop website for chemical information.Our sellers worldwide and build global on-line trade in the chemical industry. |
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