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Research Domain: Organic Phosphorus Chemistry , Bioorganic Chemistry, Origin of Life, Medicinal Chemistry.
Keyword: Yu-Fen Zhao Ph.D
Research Production: Achievement:

1. Medicine chemistry
Invented a new method to synthesize the skeleton of the Celphalatoxine,which is an anti-cancer reagent. Developed a new type of non-toxic compounds, which are highly effective for curing theschistosomiasis.

2. RNA and DNA cleavage reagents
Discovered that the N-phospho-histidine could cleave RNA and DNA by hydrolysis on the phospho-diester bond, Also found that N-phospho-serine in histidine could cleave DNA and RNA by a bio-mimic mechanism Cooperated with OhioUniversity for site specific cleavage of RNA and DNA.

3. Auto-catalysis of the N-phospho-amino acids:
It was found that N-phospho-amino acids could not only self-assemble into oligo-peptides in organic and aqueous condition from pH 2 to 9, at the temperature 0-80oC, but also phosphorylate the nucleosides into nucleotides and oligo-nucleotides. Therefore, N-phospho-amino acids could produce the peptide library,nucleotide library and the peptide-nucleotide conjugated library in one pot reaction.

4. Origin of Life
N-phospho-amino acids also could form the LB-membrane and lipsome structure, together with auto-catalysis for peptide and nucleotides formation, it was proposed as the minimum evolved system.
Remarks: Professor of Chemistry
Academician of ChineseAcademy Science.

1971 B.S., NationalTsinghuaUniversity in Taiwan

1975 Ph.D., StateUniversity of New York at Stony Brook,
Advisor: Prof. Fausto Ramirez.

1975-1979 Postdoctoral Associate,
StateUniversity of New York at Stony Brook and New York
University,

1979-1988 Associate Professor, Professor,
Institute of Chemistry Academia Sinica, Beijing

1988- Present Professor,
Department of Chemistry, TsinghuaUniversity, Beijing

1993-present Director, Bioorganic Phosphorus Chemistry Laboratrory.

1994-present Vice-Dean, School of Life Science & Engineering,TsinghuaUniversity, Beijing

1991 was elected as the youngest Member of Chinese Academy of Sciences, councilor of the Chinese Chemical Society, Full Member of the Academy of Creative Endeavors of Russia


Contact:
Department of Chemistry, Tsinghua University
Beijing 100084,China
Tel: +86-10-62785468 
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