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Prof. Jingli Yuan (born: 1963, China) obtained his Ph. D. Degree
from Waseda University (Japan) in 1997. After working in Japan
Science and Technology as a post- doctoral fellow, he got a
professor position in Dalian Institute of Chemical Physics since
2000. Prof. Yuan is the director of Molecular Probe &
Biotechnology Group and visiting associate professor of Graduate
School, Waseda University now.
Research
Introduction:
Lanthanide chelates have been successfully
developed as fluorescence probes and widely used for highly
sensitive time-resolved fluoroimmunoassay (TR-FIA), DNA
hybridization assay, high performance liquid chromatography (HPLC),
TRF bioimaging microscopy. The advantage of the microsecond TRF
measurement using lanthanide fluorescence probe is its high
sensitivity. The method permits easy distinction of specific
fluorescence signal of the long-lived label from short-lived
background signal present in most biological samples, and also
obviates the problems associated with scattering light of the
optical components, whereas these problems cannot be solved easily
by the general fluorescence methods.
Research
Focuses:
Synthesis and characterization of novel lanthanide
fluorescence probes.
Development of TRF bioassay methods,
including heterogeneous and homogeneous TR-FIA, DNA hybridization
assay, and fluorescence imaging microscopy.
R&D of lanthanide
nanoparticle fluorescence probes and their application to highly
sensitive bioassay and biotechnology. |
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1983年7月毕业于兰州大学化学系无机化学专业，1986年7月同校硕士研究生毕业(理学硕士)。1997年3月获早稻田大学理学博士学位后在日本科学技术振兴事业团CREST项目从事博士后研究。2000年3月回国任大连化学物理研究所研究员，分子探针与生物技术研究组组长，兼任早稻田大学客座副教授。
主要研究方向;
1.
功能性荧光化合物的合成及表征。该部分的研究重点为新型稀土荧光标记物的设计、制备与表征。
2．
以荧光标记物为分子探针的生物检测技术研究。该部分的研究重点包括：
(1) 高灵敏度免疫分析技术研究
(2)
高灵敏度核酸杂交分析技术研究
(3) 均相及多组分免疫分析技术和核酸杂交分析技术研究。
3．
功能性纳米荧光材料制备及相关纳米生物测定技术研究。该部分的研究重点包括：
(1)功能性纳米稀土荧光材料的制备及表征
(2)基于纳米稀土荧光材料的新型生物检测技术研究。
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