Subcellular location of PKCalphaII-GFP (green) in Green Monkey COS-7 cells using laser scanning confocal microscopy two days after transfection. The actin cytoskeleton is stained with Texas Red-phalloidin and the endoplasmic reticulum (purple) identified with an antibody to calreticulin.   By Lorene Langeberg, Scott Lab Manager at the Howard Hughes Medical Institute, Portland, OR.
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3rd Focused Meeting on PI3K signalling and disease

Bath Assembly Rooms, UK

6 - 8 November 2006

A Biochemical Society Focused Meeting

Proceedings (invited speakers) will be published in Biochemical Society Transactions.

Abstract Deadline: Monday 4 September 2006
Online Abstract submission is now open.

Early Registration Deadline: Friday 6 October 2006
After this date, an additional late fee of ?0 will be added to the registration fees.
Online registration is now open.

Student Travel Grants are available for this meeting.


Scientific Programme

Organizers
Bart Vanhaesebroeck (Ludwig Institute for Cancer Research, UK)
Brian Hemmings (Friedrich Miescher Institute for Biomedical Research, Switzerland)
Melanie Welham (University of Bath, UK)
Stephen Ward (University of Bath, UK)

Timetable

Monday 6 November 2006 Tuesday 7 November 2006 Wednesday 8 November 2006
10:15-15:15
PI3K immunology and inflammation
15:15-16:30
PI3K lipid functions and their turnover
09:00-16:45
PI3K isoforms, regulation and cell biology
09:00-10:15
PI3K downstream signalling
10:30-15:45
PI3K structural studies, inhibitors and cancer

PI3K immunology and inflammation

Monday 6 November 2006

8:00-10:00 Registration
10:00-10:15 Welcome and Introduction
10:15-10:45 Klaus Okkenhaug (The Babraham Institute, UK)
PI3K signalling in T cell activation, differentiation and regulation
10:45-11:15 Doreen Cantrell (University of Dundee, UK )
The function of PI3K signalling pathways in T lymphocytes
11:15-11:45 Akira Suzuki (Akita University, Japan)
Functions of PTEN in paraneoplastic cells such as endothelil cells and NKT cells
11:45-12:45 Lunch
12:45-13:15 Christian Rommel (Serono International S.A., Geneva)
13:15-13:30 Craig Gerard (Harvard Medical School, USA)
T-helper polarization and PI-3 kinase Gamma
13:30-13:45 Selected oral communication
13:45-14:15 John Westwick (Novartis, UK)
PI3-kinase isoforms and inflammatory diseases
14:15-14:30 Coffee/tea break
14:30-14:45 Selected oral communication
14:45-15:00 Selected oral communication
15:00-15:15 Selected oral communication

PI3K lipid functions and their turnover

Monday 6 November 2006

15:15-15:45 C. Peter Downes (University of Dundee, UK)
15:45-16:00 Stephen Ward (University of Bath, UK)
16:00-16:30 Takehiko Sasaki (Akita University, Japan)
Role of phosphoinositide phosphatase in neutrophil migration
18:00-21:00 Poster session

PI3K isoforms, regulation and cell biology

Tuesday 7 November 2006

9:00-9:30 Bart Vanhaesebroeck (Ludwig Institute for Cancer Research, UK)
9:30-9:45 Selected oral communication
9:45-10:15 Emilio Hirsch (University of Torino, Italy)
10:15-10:45 Coffee/tea break
10:45-11:15 Matthias Wymann (Centre of Biomedicine, Switzerland)
11:15-11:30 John Doukas (TargeGen, USA)
Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction
11:45-12:15 Len Stephens (The Babraham Institute, UK)
12:15-13:15 Lunch
13:15-13:45 Marco Falasca (University College London, UK)
Role of Class II PI 3-Kinase in cell signalling
13:45-14:00 Selected oral communication
14:00-14:15 Selected oral communication
14:15-14:45 Jonathan Backer (Albert Einstein College of Medicine, USA)
Regulation of class I and III PI3-kinases
14:45-15:15 Coffee/tea break
15:15-15:45 Peter Vogt (The Scripps Research Institute, USA)
Gain of Function in PI3K
15:45-16:15 Melanie Welham (University of Bath, UK)
PI3Ks and regulation of embryonic stem cell fate
16:15-16:30 Selected oral communication
16:30-16:45 Selected oral communication
16:45-17:00 Poster prize presentation
19:00-23:00 Meeting dinner incorporating Civic Reception at the Roman Baths

PI3K downstream signalling

Wednesday 8 November 2006

9:00-9:30 Brian Hemmings (Friedrich Miescher Institute for Biomedical Research, Switzerland)
9:30-9:45 Selected oral communication
9:45-10:15 George Thomas (University of Cincinnati, US)
10:15-10:30 Coffee/tea break

PI3K structural studies, inhibitors and cancer

Wednesday 8 November 2006

10:30-11:00 Roger Williams (Medical Research Council, Cambridge, UK)
11:00-11:15 Selected oral communication
11:15-11:30 Selected oral communication
11:30-12:00 Zachary Knight (University of California, USA)
12:00-13:00 Lunch
13:00-13:30 Dario Alessi (University of Dundee, UK)
PTEN, LKB1 and Cancer
13:30-13:45 Selected oral communication
13:45-14:00 Selected oral communication
14:00-14:30 Paul Workman (Cancer Research UK, London)
14:30-14:45 Coffee/tea break
14:45-15:15 Tom Crabbe (UCB, UK)
Exploring the potential of PI3K inhibitors for inflammation and oncology
15:15-15:45 Ana Carrera (National Centre of Biotechnology, Madrid)
15:45-16:00 Summary and closing remarks

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